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In the study, published today (May 1) in the journal Scientific Reports, the researchers gave the drug tadalafil (brand name Cialis) to sheep that had advanced heart failure.

The researchers found that the treatment improved the strength of the animals' heart contractions and that it reversed some of the harmful cellular effects seen in heart failure. The finding adds to a growing body of evidence suggesting that erectile dysfunction (ED) drugs could be beneficial for individuals with heart failure, a condition in which the heart muscle can't pump enough blood to meet the body's normal demands. Heart failure is a serious condition, and existing treatments aren't always effective.

About half of the people who

develop

heart failure die within five years of their diagnosis, according to the Centers for Disease Control and Prevention.

Still, because the new study was conducted in sheep, further research will be needed to see if the findings apply to humans as well. [9 New Ways to Keep Your Heart Healthy] In addition, people should not self-treat their heart failure with tadalafil, study lead author Andrew Trafford, a professor of cardiac pathophysiology at the University of Manchester in the United Kingdom, said in a statement.

Not only are more studies needed to confirm the findings, but also, tadalafil may have serious side effects when combined with other drugs.

People should speak with their doctor before taking erectile dysfunction drugs.

The most well-known ED drug, sildenafil (brand name Viagra), was originally intended as a treatment for angina, or chest pain caused by reduced blood flow to the heart.

However, in early studies, the drug did not produce the heart effects the researchers had hoped for. But it did have an interesting side effect among men: stronger and more persistent erections. This finding spurred more research and eventually led to the approval of sildenafil as an ED drug.

Sildenafil and other drugs in this class (including tadalafil) work by inhibiting an enzyme called phosphodiesterase 5 (PDE5), which is found in various tissues, including the penis, but also in blood vessels. PDE5 plays a role in regulating blood flow, and some studies suggest that PDE5 inhibitors may also affect heart cells. Although

sildenafil

didn't initially pan out as a heart drug, subsequent studies suggested that PDE5 inhibitors might have heart benefits.

For example, a 2016 study of men with type 2 diabetes who were at high risk for heart disease found that those who took PDE5 inhibitors had a lower risk of early death compared with men who didn't take the inhibitors. And a 2011 study of people with heart failure found that those who took PDE5 inhibitors experienced improvements in some of the heart abnormalities seen in patients with heart failure. However, much of this earlier research has not focused on the more advanced stages of heart failure.

In the new study, the researchers used pacemaker devices to

induce

advanced heart failure in sheep.

(The study used sheep because their hearts are similar to human hearts.) Then, the researchers administered doses of tadalafil that are similar to those used in the treatment of ED.

The researchers found that the treatment halted the progression of heart failure and reversed some of the effects seen at the cellular level in the disease. For example, it improved the ability of heart cells to respond to the hormone adrenaline. (An imparied ability of the heart to respond to adrenaline is a hallmark of heart failure, the authors said.) This, in turn, increased the ability of the heart to pump blood throughout the body. The new study "shows what people have long suspected — that there might be direct effects of [PDE5 inhibitors] on heart cells," said Dr. Theodore Abraham, professor of medicine and clinical chief of cardiology at the University of California, San Francisco, who wasn't involved in the new study. A drug that directly affects both blood vessels and heart cells would, in theory, be "the perfect combo" for treating heart failure, Abraham said. However, future studies are needed to show that PDE5 inhibitors actually improve outcomes for patients with heart failure. In the past, some drugs that directly improved heart function failed to improve outcomes (such as survival or hospitalization rates) for patients, Abraham told Live Science. In addition, future studies would need to show that PDE5 inhibitors work at least as well as or better than current drugs for heart failure and would need to determine which patients benefit most from the drugs, Abraham said. Erectile dysfunction (ED), formerly called “impotence,” means that a man often can't have an erection firm enough for intercourse.

Men with diabetes get ED three times as often as other men.

If you think you may have ED, see your health care provider.

For example, a medical problem (such as high blood pressure) may be the cause and can be

treated

. In that case, you may be able to switch to some other drug.

Sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) work by making muscles in the penis relax.

The erection-helping effects of ED pills last about 4 hours with sildenafil and vardenafil and 36 hours with tadalafil.

You should not borrow these drugs from friends or buy them online.

They should only be taken with your health care provider's knowledge and oversight.

These include men who should not have sex for medical reasons and men who take certain melrose pharmacy sildenafil drugs or have certain medical problems.

The most common

are

headache, flushing, upset stomach, vision changes, and erections that last longer than 4 hours. One form (Caverject, Caverject Impulse, or Edex) is injected into the side of the penis to increase blood flow and cause an erection within 5 to 20 minutes. Other side effects include bruising, redness, numbness, bleeding, and irritation. Alprostadil also comes as a pellet that is placed within the penis.

Side effects can include pain, aching, burning, minor bleeding, and redness.

When a man has low levels of male hormones, a doctor may prescribe testosterone patches. Too few studies have been done to know whether these patches work for ED.

The need for these can be determined with a blood test. Stress, relationship problems, and other mental factors can cause ED. Also, a man with ED may become anxious about sex,

making

ED worse.

So counseling may help even when ED has a physical cause. An elastic ring then slides onto the penis to keep the erection going after the device is removed. Blood vessel surgery helps some men, such as those with penis injuries. In another type of surgery, implants are placed in the penis. Some implants are rods that make the penis always stiff.

Other implants can be inflated to cause an erection when desired.

Today's treatments mean that most men with ED can get their sex lives back. The most important step is the first one: seek help by talking to your health care provider. Most Effect OTC Pills and Supplements for Treating Erectile Dysfunction (ED) Erectile Dysfunction, ED, affects most men around the world.

While younger men can suffer from the condition, older men, aged 70+, are the most affected. You can treat impotence with prescription medication. However, there are many over-the-counter (OTC) medications that might help manage this sexual dysfunction. Take care to ascertain whether the medications actually work and are safe for use. Most dietary supplements market themselves as “natural” pills for ED.

Let’s take a peek at these options and find out if they’re worth the hype.

Some of the dietary and herbal pills you can use to help boost sex drive include the following. DHEA (Dehydroepiandrosterone) This OTC supplement may be of help[2] if your ED isn’t due to diabetes or any nerve-related conditions.

Although, there’s not sufficient proof to justify its effectiveness.

DHEA stimulates the production of sexual hormones in men and women.

At age 30+, however, the levels of this hormone might be compromised in your body, risking[3] your chances of developing ED.

Note that you might experience the following side effects with dehydroepiandrosterone.

Acne An

urgency

to urinate Issues with sleep Aggressiveness Breast tenderness Reduced size of the testes.

DHEA is found naturally in yams (and certain soy products).

This ODC drug helps bring the ATP (adenosine triphosphate) and nitric oxide levels in the body back to normal. These two chemicals produced are responsible for giving energy and ensuring that blood flows the right way.

With no recorded side effects, ingredients like Epimedium brevicornum (horny goat weed), Panax ginseng root, pomegranate, Ginkgo Biloba, Citrus Sinensis, zinc, and Tribulus Terrestris make up the Viasil drug. Viasil gives longer and harder erections, increases

libido

, treats erectile dysfunction, and impotence.

Manufactured by leading Edge Health, the clinical trials for this drug were carried out on humans and not lab rats to prove its potency. This product has been proven to add at least 2 inches in length and 1 inch in

girth

to the penis. It also improves sexual stamina, increases testosterone level, gives bigger, harder, and lasting erections, and increases orgasms.

The major substance in Vigrx plus is Bioperine, this ingredient increases the rate at which the drug takes effect and delivers the other ingredients in the drug straight to the cells that need them.

The effect of this pill is long-lasting; this means you do not need to take the pills every time you want to have sex. One of the popular amino acid supplements, L-arginine may help treat erection problems by improving blood flow to the penis. It’s converted into nitric oxide, aiding your blood vessels to open wider.

Based on some experiments, you can pair[4] L-arginine with other ED medication, including yohimbine and glutamate. You can also combined it[5] with pycnogel – an extract of a tree bark. Side effects[6] include:

Low

levels of blood sugar Nausea Mild cramping Raise bleeding risks when combined with certain drugs.

While L-arginine has been widely used to treat[7] metabolic alkalosis in children, it’s yet to be approved as an ED treatment by FDA. Available in pill and cream form, ginseng helps boost sexual function[8] in men.

The supplement is popularly known as red ginseng, but you can also refer to it as Panax or Chinese ginseng. According to a study[9] performed on men with mild-to-moderate ED, ginseng can help improve your overall sexual satisfaction, including orgasm and sexual desire. Seek medical advice before using this common herbal pill. Note that it can cause sleeping problems, characteristic of stimulants. If you’re suffering from heart disease, bleeding conditions, or illnesses of the auto-immune system.

Ginseng can cause adverse side effects, including headaches, diarrhoea, and nausea. Still, more research should be done to ascertain it as a viable treatment for ED. A products of an African tree, Yohimbe is sold as a treatment option for erectile dysfunction. It promotes ejaculation and orgasmic function in men, according to a study[10].

Thanks to its active substance (Yohimbine), Yohimbe helps boost blood blow to the penis. It also initiates the production of norepinephrine, a neurotransmitter that aids boost erections. You might experience anxiety, irregular heartbeats, and heightened blood pressure as a result of using of using Yohimbine.

That’s why some medical experts will unlikely recommend it for you.

Note, there’s no

sufficient

evidence to support the effectiveness of Yohimbe in helping boost libido. Propionyl-L-carnitine is related to L-carnitine, an amino-acid derivative.

It helps improve blood flow and other issues stemming from the circulatory system. Several studies[11] have concluded that both L-carnitine and propionyl-L-carnitine can help boost[12] the effects of the enhancement male pill, viagra.

Some OTC pills advertised for ED are a controversial lot in the medical field.

While they may be labeled natural, they could contain harmful, hidden ingredients, according to the Food and Drug Administration, FDA.

OTC products that are supposed to enhance sex are not FDA regulated, either.

Further, certain herbs have not been tested on humans, despite their effectiveness in treating ED in animals. FDA states that approximately 300[13] ED products feature unusual amounts of undisclosed ingredients.

The organization has listed[14] some 29 “dietary pills” you should avoid.

Some

OTC

drugs for ED could interact with other erectile dysfunction drugs.

Some more may contain substances that interact with other medications you’re taking to manage other conditions.

The (OTC) medications featuring sildenafil may also interact with drugs containing nitrates, leading to a fall in blood pressure.

Consequently, if you’re treating pulmonary hypertension with traditional pills for erectile dysfunction, including the over counter Viagra pill, don’t combine them[15] with medications containing alpha-blockers and nitrates.

There isn’t sufficient evidence to prove that the above OTC drugs improve sexual performance.

Seek medical advice before using any of these dietary supplements – especially if you’re using supplementary medicines or are suffering from other health disorders.

It doesn’t matter if the pills are marketed as “natural” or not.

Unlike the OTC medications for erectile dysfunction, prescription medications are approved by the FDA.

They are prescribed by your doctor after an examination. Here are four main oral prescription medications for ED.

Viagra, sildenafil Cialis, tadalafil Staxyn (Levitra), vardenafil Stendra, avanafil. Companies like Bluechew offer sildenafil, aka generic viagra, as a monthly subscription service delivered by mail.

They only require an online assessment to be completed, making them a bit of a hybrid between OTC ED supplements and more expensive prescription ED pills like Viagra. These medications are often successful in treating erectile dysfunction. They boost the nitric oxide effects – nitric oxide is a chemical your body generates to help ease the penis muscles. You’ll still require sexual stimulation to obtain an erection with these prescription drugs. They are PDE-5 inhibitors; they don’t function like a charm.

Note, while similar, the above drugs are administered in different dosages. They have varied potential side effects, too, as is the duration of their action. Stomach upsets Headache Backache Changes in ability to see Nasal congestion. A health expert can help you choose what best works best for you.

Do not use them if you’re on nitrate drugs or have the following conditions. Liver disease Heart issues Kidney disease Uncontrolled high blood pressure. Apart from prescription medications and over the counter ED pills, you can manage erectile dysfunction using additional treatments. Medical options include: Testosterone replacement Surgery of the blood vessels Suppository of the alprostadil urethral Penis injections Penile implants Vacuum pumps.

Rhodiola Rosea might help improve sexual energy[16], based on a study.

26 men out of 35 reported an improvement in sexual activity after being treated with this herb for three months.

Nevertheless, the safety of Rhodiola Rosea isn’t yet ascertained, and the mechanism by which it works is still under research.

If your zinc levels are low, you can use zinc supplements as an alternative therapy to help boost your sex drive.

The herbs ginkgo and ashwagandha are some of the options you can use.

Note that these are still undergoing research to ascertain their effectiveness. A study[17] shows there’s a link between impotence and watermelon.

The fruit boasts citrulline, a compound that helps ease blood vessels while boosting blood flow.

According

to research[18], flavonoids can improve your cardiovascular health.

These compounds increase the strength of nitric oxide in the blood, which is key when it comes to developing and maintaining an erection.

Dark chocolate is one of the foods rich in flavonoids.

A study[19] shows improved sexual performance when you consume pick pistachios for weeks.

Pistachios can also help keep your blood pressure and cholesterol levels in check.

Results show promising results with acupuncture as an ED treatment.

One study[20] shows that acupuncture boosts the quality of erection in men.

An advanced study[21] proves that acupuncture helps enhance erection. Despite all of these, acupuncture is still undergoing research when it comes to treating erectile dysfunction.

If you’re treated by acupuncture, you’re likely to experience minimum risks[22].

ED is

associated

with insufficient blood flow to the penis.

Consequently, examine your lifestyle – some habits can compromise blood flow in your body, increasing impotence chances.



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